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Dermatomyositis (Dermatopolymyositis) Summary

Description: A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)

Also Known As: Dermatopolymyositis; Polymyositis Dermatomyositis; Dermatomyositis, Adult Type; Dermatomyositis, Childhood Type; Adult Type Dermatomyositides Show All >>

Networked: 2002 relevant articles (128 outcomes, 165 trials/studies) for this Disease

Key Drugs and Agents for Dermatomyositis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Intravenous Immunoglobulins (IVIG) : 31 outcomes 29 studies in 97 results : FDA 1
  2. Immunoglobulins (Immunoglobulin) : 16 outcomes 13 studies in 71 results : IBA
  3. Adrenal Cortex Hormones (Corticosteroids) : 15 outcomes 2 studies in 80 results : IBA
  4. Cyclosporine (Ciclosporin) : 12 outcomes 1 study in 67 results : FDA 20 Generic
  5. Methotrexate (Mexate) : 8 outcomes 2 studies in 61 results : FDA 8 Generic
  6. Tacrolimus (Prograf) : 7 outcomes 3 studies in 19 results : FDA 7 Generic
  7. rituximab (Mabthera) : 5 outcomes 4 studies in 31 results : FDA 3
  8. Cyclophosphamide (Cytoxan) : 5 outcomes 1 study in 40 results : FDA 10 Generic
  9. Prednisolone (Predate) : 4 outcomes 1 study in 31 results : FDA 55 Generic
  10. Cortisone : 3 outcomes in 18 results : IBA
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Diseases Related to Dermatomyositis

  1. Polymyositis
  2. Interstitial Lung Diseases (Interstitial Lung Disease)
  3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
  4. Inclusion Body Myositis
  5. Polyneuropathies (Polyneuropathy)
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Key Therapies for Dermatomyositis

Efficacy Chart >>
  1. Aftercare (After-Treatment) : 4 outcomes 1 study in 16 results
  2. Drug Therapy (Chemotherapy) : 4 outcomes in 24 results
  3. Transplants (Transplant) : 3 outcomes in 7 results
  4. Mesenchymal Stem Cell Transplantation : 2 outcomes in 2 results
  5. Resistance Training : 1 outcome 2 studies in 5 results
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