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Decerebrate State Summary

Description: A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)

Also Known As: Decerebrate Posturings; Decerebrate Rigidity; Decerebrate States; Decorticate Rigidities; Decorticate States Show All >>

Networked: 64 relevant articles (4 outcomes, 1 trials/studies) for this Disease

Key Drugs and Agents for Decerebrate State

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Oxazolidinones (2 Oxazolidone) : 2 outcomes in 3 results : IBA
  2. Norepinephrine (Noradrenaline) : 1 outcome in 5 results : FDA 5 Generic
  3. Propranolol (Inderal) : 1 outcome in 2 results : FDA 158 Generic
  4. Tremorine : 1 outcome in 1 result : IBA
  5. Strychnine : 1 outcome in 1 result : IBA
  6. Kynurenic Acid (Kynurenate) : 1 outcome in 1 result : IBA
  7. Ketamine : 1 outcome in 1 result : FDA 8 Generic
  8. Hexobarbital (Hexenal) : 1 outcome in 1 result : IBA
  9. Epinephrine (Adrenaline) : 1 outcome in 1 result : FDA 93 Generic
  10. 3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP) : 1 outcome in 1 result : IBA
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Diseases Related to Decerebrate State

  1. Fever (Fevers)
  2. Brain Hypoxia (Cerebral Hypoxia)
  3. Heart Arrest (Cardiac Arrest)
  4. Coma (Comas)
  5. Ventricular Fibrillation
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Key Therapies for Decerebrate State

Efficacy Chart >>
  1. Electroacupuncture : 1 study in 1 result
  2. Resuscitation : 2 results
  3. Intra-Arterial Injections : 2 results
  4. Epidural Injections : 2 results
  5. Renal Replacement Therapy (Therapies, Renal Replacement) : 1 result
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