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Crigler-Najjar Syndrome (Syndrome, Crigler-Najjar) Summary

Description: A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.

Also Known As: Syndrome, Crigler-Najjar; Crigler-Najar Syndrome; Crigler Najar Syndrome; Crigler Najjar Syndrome; Syndrome, Crigler-Najar

Networked: 172 relevant articles (4 outcomes, 10 trials/studies) for this Disease

Key Drugs and Agents for Crigler-Najjar Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Bilirubin : 2 outcomes 4 studies in 87 results : IBA
  2. Factor VII (Proconvertin) : 1 outcome in 1 result : IBA
  3. progressive familial intrahepatic 1 Cholestasis : 1 outcome in 1 result : IBA
  4. 4-O-carboxymethylascochlorin : 1 outcome in 1 result : IBA
  5. Uridine Diphosphate (UDP) : 2 studies in 20 results : IBA
  6. Transferases : 2 studies in 16 results : IBA
  7. Glucuronosyltransferase (UDP Glucuronosyltransferase) : 1 study in 35 results : IBA
  8. Glucuronides : 1 study in 4 results : IBA
  9. Nonsense Codon (Nonsense Mutation) : 1 study in 3 results : IBA
  10. Complementary DNA (cDNA) : 1 study in 2 results : IBA
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Diseases Related to Crigler-Najjar Syndrome

  1. Hyperbilirubinemia
  2. Ornithine Carbamoyltransferase Deficiency Disease
  3. Gilbert Disease
  4. Jaundice
  5. Neonatal Hyperbilirubinemia
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Key Therapies for Crigler-Najjar Syndrome

Efficacy Chart >>
  1. Liver Transplantation : 1 outcome 1 study in 18 results
  2. Homologous Transplantation (Allograft) : 1 outcome in 1 result
  3. Injections : 1 outcome in 1 result
  4. Transplantation (Transplant Recipients) : 1 study in 9 results
  5. Transplants (Transplant) : 1 study in 6 results
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