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Clozapine (Clozaril) Summary

Description: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Also Known As: Clozaril; Leponex; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-

Networked: 4163 relevant articles (509 outcomes, 749 trials/studies) for this Drug

Key Diseases for which Clozapine is Relevant

  1. Schizophrenia (Dementia Praecox) : 315 outcomes 465 studies in 1947 results
  2. Agranulocytosis (Granulocytopenia) : 29 outcomes 33 studies in 434 results
  3. Psychotic Disorders (Schizoaffective Disorder) : 26 outcomes 71 studies in 232 results
  4. Bipolar Disorder (Mania) : 25 outcomes 23 studies in 113 results
  5. Movement Disorders (Movement Disorder) : 22 outcomes 16 studies in 164 results
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Drugs Related to Clozapine

  1. Antipsychotic Agents (Antipsychotics)
  2. olanzapine (Zyprexa)
  3. Risperidone (Risperdal Consta)
  4. quetiapine (Seroquel)
  5. Haloperidol (Haldol)
  6. ziprasidone (Geodon)
  7. aripiprazole (Abilify)
  8. Levodopa (L Dopa)
  9. Lithium
  10. sultopride (amisulpride)
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Therapies Related to Clozapine

  1. Drug Therapy (Chemotherapy)
  2. Polypharmacy
  3. Aftercare (After-Treatment)
  4. Injections
  5. Withholding Treatment
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