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Microbial Collagenase (Clostridiopeptidase A) Summary

Description: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC

Also Known As: Clostridiopeptidase A; Clostridium histolyticum Collagenase; Collagenase-Like Peptidase; Collalysine; Nucleolysin Show All >>

Networked: 100 relevant articles (9 outcomes, 35 trials/studies) for this Bio-Agent

Key Diseases for which Microbial Collagenase is Relevant

  1. Dupuytren Contracture (Dupuytrens Contracture) : 6 outcomes 15 studies in 48 results
  2. Penile Induration (Peyronie's Disease) : 3 outcomes 14 studies in 23 results
  3. Contracture : 1 outcome 4 studies in 16 results
  4. Congenital Abnormalities (Deformity) : 2 studies in 2 results
  5. Leiomyoma (Uterine Fibroids) : 1 study in 1 result
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Drugs Related to Microbial Collagenase

  1. Collagenases (Collagenase)
  2. Collagen
  3. Interferons
  4. propylene diquat (PDQ(+))
  5. prolyl oligopeptidase (prolyl endopeptidase)
  6. Matrix Metalloproteinases
  7. Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
  8. Peptide Hydrolases (Proteases)
  9. Ions
  10. Immunoglobulin G (IgG)
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Therapies Related to Microbial Collagenase

  1. Injections
  2. Intralesional Injections
  3. Debridement
  4. Phonophoresis
  5. Transplants (Transplant)
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