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Microbial Collagenase (Clostridiopeptidase A) Summary

Description: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.

Also Known As: Clostridiopeptidase A; Clostridium histolyticum Collagenase; Collagenase-Like Peptidase; Collalysine; Nucleolysin Show All >>

Networked: 100 relevant articles (9 outcomes, 35 trials/studies) for this Bio-Agent

Key Diseases for which Microbial Collagenase is Relevant

  1. Dupuytren Contracture (Dupuytrens Contracture) : 6 outcomes 15 studies in 48 results
  2. Penile Induration (Peyronie's Disease) : 3 outcomes 14 studies in 23 results
  3. Contracture : 1 outcome 4 studies in 16 results
  4. Congenital Abnormalities (Deformity) : 2 studies in 2 results
  5. Leiomyoma (Uterine Fibroids) : 1 study in 1 result
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Drugs Related to Microbial Collagenase

  1. Collagenases (Collagenase)
  2. Collagen
  3. Interferons
  4. propylene diquat (PDQ(+))
  5. prolyl oligopeptidase (prolyl endopeptidase)
  6. Matrix Metalloproteinases
  7. Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
  8. Peptide Hydrolases (Proteases)
  9. Ions
  10. Immunoglobulin G (IgG)
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Therapies Related to Microbial Collagenase

  1. Injections
  2. Intralesional Injections
  3. Debridement
  4. Phonophoresis
  5. Transplants (Transplant)
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