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Bowen's Disease (Disease, Bowen) Summary

Description: A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)

Also Known As: Disease, Bowen; Bowen Disease; Bowens Disease; Disease, Bowen's

Networked: 607 relevant articles (59 outcomes, 61 trials/studies) for this Disease

Key Drugs and Agents for Bowen's Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. 1-phenyl-3,3-dimethyltriazene (PDT) : 30 outcomes 13 studies in 94 results : IBA
  2. imiquimod (Aldara) : 10 outcomes 5 studies in 60 results : FDA 4 Generic
  3. Fluorouracil (Carac) : 5 outcomes 1 study in 26 results : FDA 33 Generic
  4. Arsenic : 2 outcomes 3 studies in 47 results : IBA
  5. Aminolevulinic Acid (Levulan) : 2 outcomes 3 studies in 9 results : FDA 1
  6. Keratins (Keratin) : 1 outcome 4 studies in 15 results : IBA
  7. Antibodies : 1 outcome 3 studies in 11 results : IBA
  8. Antigens : 1 outcome 2 studies in 14 results : IBA
  9. Cadherins (E-Cadherin) : 1 outcome 2 studies in 7 results : IBA
  10. Acitretin : 1 outcome 2 studies in 3 results : FDA 1
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Diseases Related to Bowen's Disease

  1. Basal Cell Carcinoma (Rodent Ulcer)
  2. Actinic Keratosis
  3. Squamous Cell Carcinoma (Epidermoid Carcinoma)
  4. Neoplasms (Cancer)
  5. Keratosis
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Key Therapies for Bowen's Disease

Efficacy Chart >>
  1. Photochemotherapy (Photodynamic Therapy) : 19 outcomes 12 studies in 107 results
  2. Cryotherapy (Therapy, Cold) : 3 outcomes 2 studies in 18 results
  3. Gas Lasers : 3 outcomes 2 studies in 12 results
  4. Radiotherapy : 2 outcomes in 13 results
  5. Dye Lasers : 1 outcome 1 study in 4 results
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