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Aromatase (CYP19) Summary

Description: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.

Also Known As: CYP19; Androstenedione Aromatase; CYP 19; CYP19 Protein; Cytochrome P450 19 Show All >>

Networked: 3173 relevant articles (196 outcomes, 644 trials/studies) for this Bio-Agent

Key Diseases for which Aromatase is Relevant

  1. Breast Neoplasms (Breast Cancer) : 118 outcomes 347 studies in 1623 results
  2. Neoplasms (Cancer) : 31 outcomes 107 studies in 696 results
  3. Endometriosis (Adenomyosis) : 12 outcomes 22 studies in 156 results
  4. Carcinoma (Carcinomatosis) : 6 outcomes 38 studies in 149 results
  5. Pain (Aches) : 4 outcomes 10 studies in 37 results
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Drugs Related to Aromatase

  1. Hormones
  2. letrozole (Femara)
  3. Estrogens (Estrogen)
  4. anastrozole (Arimidex)
  5. Tamoxifen
  6. exemestane (Aromasin)
  7. Aromatase Inhibitors
  8. Estrogen Receptor Modulators (Antiestrogen)
  9. Enzymes
  10. Aromatase (CYP19)
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Therapies Related to Aromatase

  1. Heterologous Transplantation (Xenotransplantation)
  2. Drug Therapy (Chemotherapy)
  3. Chemoprevention
  4. Ovariectomy (Oophorectomy)
  5. Oral Administration
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