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Histocompatibility Antigens Class II Summary

Description: Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

Also Known As: Class II Antigen; Class II Histocompatibility Antigens; Class II Major Histocompatibility Antigens; I-A Antigen; I-A-Antigen Show All >>

Networked: 1508 relevant articles (19 outcomes, 111 trials/studies) for this Bio-Agent

Key Diseases for which Histocompatibility Antigens Class II is Relevant

  1. Infection : 4 outcomes 6 studies in 126 results
  2. Neoplasms (Cancer) : 3 outcomes 11 studies in 214 results
  3. Melanoma (Melanoma, Malignant) : 3 outcomes 4 studies in 73 results
  4. Leukemia : 2 outcomes 1 study in 25 results
  5. Inflammation : 1 outcome 1 study in 46 results
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Drugs Related to Histocompatibility Antigens Class II

  1. Antigens
  2. HLA-DR Antigens (HLA-DR)
  3. HLA-DQ Antigens (HLA-DQ)
  4. DNA (Deoxyribonucleic Acid)
  5. Isoantigens (Alloantigen)
  6. I-antigen
  7. Proteins (Proteins, Gene)
  8. HLA-DP Antigens (HLA-DP)
  9. HLA-DR8
  10. N-Acetylneuraminic Acid (Sialic Acid)
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Therapies Related to Histocompatibility Antigens Class II

  1. Immunotherapy
  2. Homologous Transplantation (Allograft)
  3. Ligation
  4. Transplants (Transplant)
  5. Transplantation (Transplant Recipients)
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