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Non-Steroidal Anti-Inflammatory Agents (NSAIDs) Summary

Description: Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)

Also Known As: NSAIDs; Anti-Inflammatory Agents, Non-Steroidal; Anti Inflammatory Agents, Nonsteroidal; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal Show All >>

Networked: 8202 relevant articles (752 outcomes, 1294 trials/studies) for this Bio-Agent

Key Diseases for which Non-Steroidal Anti-Inflammatory Agents is Relevant

  1. Pain (Aches) : 262 outcomes 171 studies in 1566 results
  2. Inflammation : 60 outcomes 57 studies in 674 results
  3. Osteoarthritis : 55 outcomes 99 studies in 452 results
  4. Neoplasms (Cancer) : 52 outcomes 124 studies in 633 results
  5. Rheumatoid Arthritis : 32 outcomes 70 studies in 360 results
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Drugs Related to Non-Steroidal Anti-Inflammatory Agents

  1. Aspirin (Acetylsalicylic Acid)
  2. Acetaminophen (Paracetamol)
  3. Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
  4. Opioid Analgesics (Opioids)
  5. Analgesics (Analgesic Drugs)
  6. celecoxib (Celebrex)
  7. Ibuprofen (Motrin)
  8. Adrenal Cortex Hormones (Corticosteroids)
  9. Naproxen (Naprosyn)
  10. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
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Therapies Related to Non-Steroidal Anti-Inflammatory Agents

  1. Chemoprevention
  2. Injections
  3. Analgesia
  4. Drug Therapy (Chemotherapy)
  5. Aftercare (After-Treatment)
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