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transglutaminase 1 Summary

Description: TRANSGLUTAMINASE 1 (TGM1 or TGK) is a membrane-associated enzyme involved in the formation of the cornified cell envelope of the EPIDERMIS; Mutations in the human gene (14q11) cause autosomal recessive lamellar ICHTHYOSIS; Distinguish from GAMMA-GLUTAMYLTRANSPEPTIDASE involved with glutathione metabolism and other protein cross-linking transglutaminase; RefSeq NM_019984 (mouse), NM_031659 (rat), NM_000359 (human)

Also Known As: TGASE, human; TGK protein, human; TGM1 protein; TGM1 protein, human; TGase 1, mouse Show All >>

Networked: 81 relevant articles (1 outcomes, 2 trials/studies) for this Bio-Agent

Key Diseases for which transglutaminase 1 is Relevant

  1. Psoriasis (Pustulosis Palmaris et Plantaris) : 1 outcome in 4 results
  2. Lamellar Ichthyosis (Harlequin Ichthyosis) : 2 studies in 37 results
  3. Ichthyosis (Xeroderma) : 21 results
  4. Congenital Ichthyosiform Erythroderma : 5 results
  5. Squamous Cell Carcinoma (Epidermoid Carcinoma) : 5 results
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Drugs Related to transglutaminase 1

  1. paricalcitol (Zemplar)
  2. Keratins (Keratin)
  3. Messenger RNA (mRNA)
  4. involucrin
  5. Proteins (Proteins, Gene)
  6. loricrin
  7. filaggrin
  8. Keratin-16 (Keratin 16)
  9. Steryl-Sulfatase (Steroid Sulfatase)
  10. Proliferating Cell Nuclear Antigen (PCNA)
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Therapies Related to transglutaminase 1


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