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cyclo(Trp-Asp-Pro-Val-Leu) Summary

Description: derived from the modification of a natural lead of BE-18257B, an endothelin A receptor antagonist; has neuroprotective activity; amino acid sequence given in first source

Also Known As: BQ 123; BQ-123; BQ123; cyclo(D-Trp-D-Asp-Pro-D-Val-Leu); Cyclo(D-alpha-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

Networked: 249 relevant articles (17 outcomes, 36 trials/studies) for this Bio-Agent

Key Diseases for which cyclo(Trp-Asp-Pro-Val-Leu) is Relevant

  1. Heart Failure : 6 outcomes 1 study in 10 results
  2. Pulmonary Hypertension (Ayerza Syndrome) : 1 outcome 2 studies in 12 results
  3. Pancreatitis : 1 outcome 2 studies in 4 results
  4. Myocardial Ischemia (Ischemic Heart Diseases) : 1 outcome 2 studies in 3 results
  5. Fibrosis (Cirrhosis) : 1 outcome 1 study in 5 results
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Drugs Related to cyclo(Trp-Asp-Pro-Val-Leu)

  1. Endothelins (Endothelin)
  2. bosentan (Tracleer)
  3. Endothelin Receptors (Endothelin Receptor)
  4. Endothelin A Receptor
  5. Endothelin-1 (Endothelin 1)
  6. BQ 788
  7. Ramipril (Altace)
  8. Pentylenetetrazole (Metrazol)
  9. Acetaminophen (Paracetamol)
  10. SB 209670
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Therapies Related to cyclo(Trp-Asp-Pro-Val-Leu)

  1. Analgesia
  2. Heart Transplantation (Grafting, Heart)
  3. Intra-Arterial Infusions
  4. Injections
  5. Angioplasty (Angioplasty, Transluminal)
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