Effect of immune priming on Borna disease.

Abstract

Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.

• Authors: A J Lewis, J L Whitton, C G Hatalski, H Weissenböck, W I Lipkin
• Journal: Journal of virology (J Virol) Vol. 73 Issue 3 Pg. 2541-6 (Mar 1999) ISSN: 0022-538X [Print] United States
• PMID: 9971840 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Viral
• Nucleoproteins
• RNA, Viral
• Viral Vaccines

Topics

• Animals
• Antibodies, Viral (blood)
• Borna Disease (immunology)
• HeLa Cells
• Humans
• Immunization
• Male
• Nucleoproteins (immunology)
• RNA, Viral (analysis)
• Rats
• Rats, Inbred Lew
• Viral Vaccines (immunology)