A multicenter placebo-controlled, double-blind trial of urapidil, an alpha-blocker, on neurogenic bladder dysfunction.

Abstract

OBJECTIVES:

To assess the efficacy of urapidil, an alpha-blocker, on neurogenic bladder dysfunction in a placebo-controlled, double-blind trial.

METHODS:

149 patients were randomly assigned to receive a placebo or 60 mg/day of urapidil for 4 weeks. The evaluation of efficacy included changes in urinary symptom scores and the results of a pressure/flow study.

RESULTS:

There were significant intergroup differences with regard to straining and the sum of urinary symptom scores, with the urapidil group showing marked improvements (p = 0.016 and p = 0.011, respectively). In the urapidil group, the average and maximum flow rates were unchanged, but the residual urine volume decreased significantly (p < 0.001) as compared with the baseline value. The pressure at maximum flow and the minimum urethral resistance decreased significantly (p = 0.040 and p = 0.040, respectively) in the urapidil group, and there was a significant (p = 0.005) intergroup difference with regard to pressure at maximum flow. There was also a significant (p < 0.001) inter-group difference with regard to the overall therapeutic effect. Side effects were noted in 2 patients treated with urapidil and 6 in the placebo group.

CONCLUSION:

Urapidil is effective for the treatment of voiding dysfunction in patients with neurogenic bladder.

• Authors: T Yamanishi, K Yasuda, Y Homma, K Kawabe, T Morita
• Journal: European urology (Eur Urol) Vol. 35 Issue 1 Pg. 45-51 (Jan 1999) ISSN: 0302-2838 [Print] Switzerland
• PMID: 9933794 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Adrenergic alpha-Antagonists
• Piperazines
• urapidil

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Double-Blind Method
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Piperazines (therapeutic use)
• Treatment Outcome
• Urinary Bladder, Neurogenic (drug therapy, physiopathology)
• Urodynamics (drug effects)