Abstract |
The aim of this manuscript is to introduce Cryptotis parva (the least shrew) as a new experimental emesis model. The chemotherapeutic agent, cisplatin, caused a dose-dependent increase in the number of animals exhibiting vomiting and retching behaviours with ED50 values of 6.43+/-1 and 7.9+/-1.2 mg/kg, respectively. The frequencies of these parameters were also dose-dependent. Intraperitoneal administration of 5-HT3 receptor antagonists ( tropisetron or MDL 72222) prevented cisplatin-induced emesis and retching behaviours in the least shrew by a dose-dependent mechanism with respective ID50 values of 4.28+/-2.8 and 2.05+/-2 for emesis, and 2.71+/-4.5 and 2.52+/-2.59 for retching. Intraperitoneal injection of selective and nonselective 5-HT3 receptor agonists potently, and in a dose-dependent fashion, induced emesis in the least shrew with the following ED50 potency order: 2-methyl 5-HT approximately 5-HT (p > 0.05) <5-HTQ (p < 0.01) < mCPBG (p < 0.001). As with other established experimental animal emesis models, the present data indicate that cisplatin causes emesis by activating 5-HT3 receptors indirectly via release of 5-HT.
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Authors | N A Darmani |
Journal | Journal of neural transmission (Vienna, Austria : 1996)
(J Neural Transm (Vienna))
Vol. 105
Issue 10-12
Pg. 1143-54
( 1998)
ISSN: 0300-9564 [Print] Austria |
PMID | 9928884
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antiemetics
- Antineoplastic Agents
- Drug Combinations
- Indoles
- Serotonin Antagonists
- Serotonin Receptor Agonists
- Tropanes
- creatinine sulfate, serotonin drug combination
- Serotonin
- Tropisetron
- Creatinine
- bemesetron
- Cisplatin
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Topics |
- Analysis of Variance
- Animals
- Antiemetics
(pharmacology)
- Antineoplastic Agents
(antagonists & inhibitors, toxicity)
- Cisplatin
(antagonists & inhibitors, toxicity)
- Creatinine
(analogs & derivatives, pharmacology)
- Dose-Response Relationship, Drug
- Drug Combinations
- Female
- Indoles
(pharmacology)
- Male
- Serotonin
- Serotonin Antagonists
(pharmacology)
- Serotonin Receptor Agonists
(pharmacology)
- Shrews
- Tropanes
(pharmacology)
- Tropisetron
- Vomiting
(chemically induced, prevention & control)
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