[The effect of linoleyl hydroxamic acid on lipid peroxidation processes and on the enzymatic activity of the antioxidant system in rats under hypoxia].

Abstract

It was studied the effect of new blocker of lipoxygenase way of arachidontic acid metabolism--linoleyl-hydroxamic acid--on the status of lipid peroxidation and antioxidant system in blood, heart, liver, lung and brain in rats under acute hypoxic hypoxia. It was shows that preliminary introduction of this substance lead to increase of antioxidant enzymes activity--superoxide dismutase and ceruloplasmine, and to decrease of lipid peroxidation level during hypoxia in blood, heart, liver and lung (without brain).

• Authors: T V Kukoba, M M Seredenko, I A Butovych, O O Moĭbenko
• Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) (Fiziol Zh (1994)) Vol. 44 Issue 5-6 Pg. 43-8 ( 1998) ISSN: 2522-9028 [Print] Ukraine
• Vernacular Title: Vplyv linoleïl-hidroksamovoï kysloty na stan protsesiv perekysnoho okyslennia lipidiv ta aktyvnist' fermentiv antyoksydantnoï systemy shchuriv pry hipoksiï.
• PMID: 9866024 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antioxidants
• Hydroxamic Acids
• Linoleic Acids
• Lipid Peroxides
• Lipoxygenase Inhibitors
• linoleic acid hydroxamate
• Superoxide Dismutase
• Ceruloplasmin

Topics

• Acute Disease
• Animals
• Antioxidants (metabolism)
• Ceruloplasmin (drug effects, metabolism)
• Hydroxamic Acids (pharmacology)
• Hypoxia (metabolism)
• Linoleic Acids (pharmacology)
• Lipid Peroxidation (drug effects)
• Lipid Peroxides (metabolism)
• Lipoxygenase Inhibitors (pharmacology)
• Male
• Rats
• Rats, Wistar
• Superoxide Dismutase (drug effects, metabolism)