Abstract | PURPOSE: MATERIALS AND METHODS: The authors performed planar Ga-67 and Tl-201 scintigraphy in 39 patients aged 7-18 years (27 with mediastinal primary disease) after primary treatment. These scans and those in a control group of 14 patients with newly diagnosed known mediastinal Hodgkin disease were evaluated independently by two radiologists for abnormal mediastinal activity. Results were compared with chest computed tomographic (CT) findings and with the clinical criteria of disease status. Interobserver agreement and consensus agreement on gallium and thallium scan findings were evaluated with the kappa statistic, and the specificity of the two imaging methods was analyzed. RESULTS: All study patients were judged to be free of mediastinal disease with CT and the clinical criteria. Interobserver agreement on findings in the treated and control patients was stronger with gallium scintigraphy (kappa +/- SD = 0.956 +/- 0.044) than with thallium scintigraphy (kappa = 0.638 +/- 0.110). Specificity of ratings based on thallium (85% +/- 6) and gallium (90% +/- 5) scintigraphic findings of mediastinal disease did not differ significantly (P = .48). Specificity improved when the results of the two examinations were combined (97% +/- 2). CONCLUSION:
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Authors | B D Fletcher, X Xiong, W M Kauffman, S C Kaste, M M Hudson |
Journal | Radiology
(Radiology)
Vol. 209
Issue 2
Pg. 471-5
(Nov 1998)
ISSN: 0033-8419 [Print] United States |
PMID | 9807576
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Gallium Radioisotopes
- Thallium Radioisotopes
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Topics |
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Case-Control Studies
- Child
- Combined Modality Therapy
- Gallium Radioisotopes
- Hodgkin Disease
(diagnostic imaging, therapy)
- Humans
- Mediastinal Neoplasms
(diagnostic imaging, therapy)
- Radionuclide Imaging
- Radiotherapy Dosage
- Sensitivity and Specificity
- Thallium Radioisotopes
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