Identification of mammaglobin B, a novel member of the uteroglobin gene family.

Abstract	In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.
Authors	R M Becker, C Darrow, D B Zimonjic, N C Popescu, M A Watson, T P Fleming
Journal	Genomics (Genomics) Vol. 54 Issue 1 Pg. 70-8 (Nov 15 1998) ISSN: 0888-7543 [Print] United States
PMID	9806831 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Copyright	Copyright 1998 Academic Press.
Chemical References	Mammaglobin A Mammaglobin B Myelin Proteins Neoplasm Proteins Proteins Proteolipids RNA, Messenger SCGB1A1 protein, human SCGB2A1 protein, human SCGB2A2 protein, human Scgb1a1 protein, rat Secretoglobins Uteroglobin
Topics	Amino Acid Sequence Animals Base Sequence Blotting, Northern Breast (metabolism) Breast Neoplasms (metabolism) Chromosomes, Human, Pair 11 (genetics) Female Humans In Situ Hybridization, Fluorescence Mammaglobin A Mammaglobin B Molecular Sequence Data Myelin Proteins Neoplasm Proteins (chemistry, genetics, metabolism) Polymerase Chain Reaction Proteins (genetics) Proteolipids RNA, Messenger (genetics, metabolism) Salivary Glands (metabolism) Secretoglobins Uterine Neoplasms (metabolism) Uteroglobin (chemistry, genetics, metabolism) Uterus (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!