HLA and HPA typing in idiopathic thrombocytopenic purpura patients treated with Kami-kihi-to.

Abstract

We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytopenic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 *0901, DRB1 *1502, and DPB1 *0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a/a genotype of HPA-3 were markedly increased in nonresponders, and anti-GPIb antibody was also increased. These results suggest that HLA, HPA, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to.

• Authors: T Matsuzaki, S Nomura, M Yamaoka, Y Ozaki, C Yoshimura, G L Xie, K Katsura, H Kagawa, T Ishida, S Fukuhara
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 26 Issue 2 Pg. 191-8 ( 1998) ISSN: 0192-415X [Print] Singapore
• PMID: 9799971 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Human Platelet
• Drugs, Chinese Herbal
• HLA Antigens
• HLA-A2 Antigen
• HLA-B Antigens
• HLA-B61 antigen
• HLA-C Antigens
• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Antigens, Human Platelet (classification, genetics)
• Drugs, Chinese Herbal (therapeutic use)
• Female
• HLA Antigens (classification, genetics)
• HLA-A2 Antigen (classification, genetics)
• HLA-B Antigens (classification, genetics)
• HLA-C Antigens (classification, genetics)
• HLA-DR Antigens (classification, genetics)
• HLA-DRB1 Chains
• Histocompatibility Testing
• Humans
• Male
• Purpura, Thrombocytopenic, Idiopathic (drug therapy, immunology)