The corrected TIMI frame count. The new gold standard?
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| Abstract |
Over the last decade Thrombolysis in Myocardial Infarction (TIMI) flow grades have been the gold standard for the assessment of efficacy of infarct-artery reperfusion. However, with the introduction of core angiographic laboratories, the reproducibility of TIMI flow grades has been questioned. The corrected TIMI frame count (CTFC) has been developed as a more reproducible method of quantifying infarct artery blood flow after myocardial infarction (MI). We have utilised the CTFC in two studies to examine infarct-artery blood flow. In the Hirulog in Early Reperfusion and Occlusion (HERO 1) study, the CTFC was measured at 90-120 minutes after administration of aspirin, streptokinase and either Hirulog or heparin. Only 27% of patients had a normal CTFC (< or = 27) in the infarct-related artery. Patients with a prolonged CTFC (> 27) had more abnormal left ventricular function (LVF) as measured by the mean chord score in the 'area at risk' (-2.51 vs -2.06, p = 0.02), on left ventriculography. In a second study, infarct-artery flow was examined four weeks and one year after MI. At four weeks, only 43% of patients with patient infarct-related arteries had a 'normal' CTFC of < or = 27. A prolonged CTFC at four weeks was a univariate predictor of increased reocclusion at one year (p = 0.001). CTFCs are frequently abnormal in patent infarct-related arteries, and predict reocclusion. Whether frame counting is a better predictor of late clinical outcomes than the TIMI flow grade needs to be prospectively examined in large clinical trials.
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| Authors | J K French, C J Ellis, H D White |
| Journal | Australian and New Zealand journal of medicine (Aust N Z J Med) Vol. 28 Issue 4 Pg. 569-73 (Aug 1998) ISSN: 0004-8291 [Print] Australia |
| PMID | 9777142 (Publication Type: Journal Article) |
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