Abstract | BACKGROUND AND OBJECTIVE: DESIGN AND METHODS: RESULTS: The median days to reach > 0.5 x 10(9)/L granulocytes was similar for patients receiving filgrastrim (10.5 +/- 0.8 days) and molgramostim (10.2 +/- 0.9 days). No significant differences were observed in time taken to reach 20 x 10(9)/L platelets 10.8 +/- 2.2 vs 12 +/- 2.9 for filgrastrim and molgramostim, respectively, but in time to reach 50 x 10(9)/L was slightly lower in the filgrastrim arm (15.1 +/- 2.9 vs 18.9 +/- 8.4, p = 0.03). Nevertheless there were no differences in the number of platelets transfused. Time of discharge was two days earlier in the filgrastrim arm (15 +/- 4.2 vs 17.4 +/- 4.7, p = 0.04). Finally, the incidence of adverse side effects attributable to the cytokines (filgrastrim or molgramostim) was equivalent and only present in 19% of the patients. INTERPRETATION AND CONCLUSIONS: This randomized study shows that filgrastrim and molgramostim yield quite similar toxicity and efficacy for early hematopoietic reconstitution after PBSCT in breast cancer patients.
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Authors | M D Caballero, L Vazquez, J M Barragan, J J Cruz, A Gomez, M J Nieto, M Corral, E Fonseca, J F San Miguel |
Journal | Haematologica
(Haematologica)
Vol. 83
Issue 6
Pg. 514-8
(Jun 1998)
ISSN: 0390-6078 [Print] Italy |
PMID | 9676024
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antineoplastic Agents
- Recombinant Proteins
- Granulocyte Colony-Stimulating Factor
- Granulocyte-Macrophage Colony-Stimulating Factor
- molgramostim
- Filgrastim
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Topics |
- Administration, Cutaneous
- Adult
- Antineoplastic Agents
(administration & dosage)
- Breast Neoplasms
(therapy)
- Female
- Filgrastim
- Granulocyte Colony-Stimulating Factor
(administration & dosage, adverse effects)
- Granulocyte-Macrophage Colony-Stimulating Factor
(administration & dosage, adverse effects)
- Hematopoiesis
(drug effects)
- Hematopoietic Stem Cell Transplantation
- Humans
- Middle Aged
- Recombinant Proteins
(administration & dosage, adverse effects)
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