Abstract | BACKGROUND: AIMS: PATIENTS: METHODS: Patients received either bismuth carbomer (270 mg elemental bismuth) (n = 20) or placebo (n = 20) foam enemas for 3 weeks. Clinical assessment was performed at baseline and at 3 weeks using the pouchitis disease activity index score which incorporates symptoms, endoscopy and histology. Serum bismuth concentrations were determined by atomic absorption spectrophotometry. RESULTS: At 3 weeks nine of 20 patients (45%) in both the bismuth and placebo groups had improved. Ten patients discontinued prematurely because of worse diarrhoea (three in each group) or abdominal cramping after enema use (one from the bismuth group and three from the placebo group). No other side-effects were noted. Serum bismuth concentrations were negligible in all patients. CONCLUSIONS:
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Authors | W J Tremaine, W J Sandborn, B G Wolff, H A Carpenter, A R Zinsmeister, P P Metzger |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 11
Issue 6
Pg. 1041-6
(Dec 1997)
ISSN: 0269-2813 [Print] England |
PMID | 9663827
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gastrointestinal Agents
- Placebos
- Bismuth
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Topics |
- Adolescent
- Adult
- Bismuth
(administration & dosage, adverse effects)
- Chronic Disease
- Double-Blind Method
- Enema
- Female
- Gastrointestinal Agents
(administration & dosage, adverse effects)
- Humans
- Male
- Middle Aged
- Placebos
- Pouchitis
(drug therapy)
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