5-hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart.

Abstract

The aim of the present study was to determine the effect of 5-hydroxydecanoate (5-HD) on extracellular K+ levels during global ischemia for 30 min employing K+-sensitive electrodes in isolated guinea-pig hearts. 5-HD (100 microM) reduced the K+ accumulation during the early period of ischemia, but did not inhibit the elevation of extracellular K+ in the latter half of the ischemic period which was selectively enhanced by ouabain (3 microM). Thus, 5-HD appears to exert a similar mode of action as glibenclamide on extracellular K+ accumulation in the ischemic guinea-pig hearts. The present study also strengthens the previous conclusion that an ATP-sensitive K+ channel contributes only to the initial increasing phase of extracellular K+ accumulation during ischemia in guinea-pig hearts.

• Authors: K Sakamoto, J Yamazaki, T Nagao
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 348 Issue 1 Pg. 31-5 (May 01 1998) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9650828 (Publication Type: Journal Article)

Chemical References

• Cardiovascular Agents
• Decanoic Acids
• Hydroxy Acids
• Potassium Channel Blockers
• Ouabain
• 5-hydroxydecanoic acid
• Potassium

Topics

• Animals
• Cardiovascular Agents (pharmacology)
• Decanoic Acids (pharmacology)
• Guinea Pigs
• Heart (drug effects)
• Hydroxy Acids (pharmacology)
• In Vitro Techniques
• Male
• Myocardial Contraction (drug effects)
• Myocardial Ischemia (physiopathology)
• Myocardium (metabolism)
• Ouabain (pharmacology)
• Potassium (metabolism, pharmacology)
• Potassium Channel Blockers