Inhibitory effect of 2,5-dimethylpyrazine on oxytocic agent-induced uterine hypercontraction of normal or pregnant female rats.

Abstract

Intraperitoneal administration of 2,5-dimethylpyrazine (2,5-DMP) was found to inhibit oxytocin- and prostaglandin F2alpha-induced tetanic uterine contractions in normal or pregnant female rats. This suggests that 2,5-DMP may be used as a countercontraction agent or relaxant for preventing oxytocic agent-induced medical accident including uterine rupture or pressure death of the fetus due to uterine contractions.

• Authors: K Yamada, Y Kobayashi, H Fujihara, A Ohta
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 21 Issue 5 Pg. 538-40 (May 1998) ISSN: 0918-6158 [Print] Japan
• PMID: 9635516 (Publication Type: Journal Article)

Chemical References

• Oxytocics
• Pyrazines
• Oxytocin
• Dinoprost
• 2,5-dimethylpyrazine

Topics

• Animals
• Dinoprost (antagonists & inhibitors, pharmacology)
• Electromyography
• Female
• Injections, Intraperitoneal
• Oxytocics (administration & dosage, antagonists & inhibitors, pharmacology)
• Oxytocin (antagonists & inhibitors, pharmacology)
• Pregnancy
• Pregnancy, Animal (physiology)
• Pyrazines (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Uterine Contraction (drug effects)