Technetium 99m glucarate: what will be its clinical role?

Abstract

With publication of the studies by Khaw et al. and Beanlands et al. in this issue of the Journal, there is mounting evidence that 99mTc glucarate is taken up by infarcted but not by ischemic myocardium. The early myocardial distribution and rapid blood-pool clearance of 99mTc glucarate suggest important diagnostic potential in the very early detection of acute myocardial infarction and for the identification of successful acute revascularization therapy. To understand the full diagnostic implications of 99mTc glucarate accumulation in the myocardium, larger human trials are now needed. It will be critically important to document the capabilities of 99mTc glucarate to identify, early on, acute myocardial infarction in the presence of a persistently occluded infarct-related coronary artery in human beings.

• Authors: M C Gerson, A J McGoron
• Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (J Nucl Cardiol) 1997 Jul-Aug Vol. 4 Issue 4 Pg. 336-40 ISSN: 1071-3581 [Print] United States
• PMID: 9278881 (Publication Type: Editorial)

Chemical References

• Antibodies, Monoclonal
• Organometallic Compounds
• Organotechnetium Compounds
• imciromab pentetate
• Technetium Tc 99m Pyrophosphate
• Glucaric Acid

Topics

• Antibodies, Monoclonal
• Glucaric Acid (pharmacokinetics)
• Humans
• Myocardial Ischemia (diagnostic imaging)
• Myocardium (pathology)
• Necrosis
• Organometallic Compounds
• Organotechnetium Compounds
• Radionuclide Imaging
• Technetium Tc 99m Pyrophosphate