Collagen diseases and the biosynthesis of collagen.

Abstract

Increasing knowledge concerning the molecular structure of collagen and the steps involved in its biosynthesis provides the basis for a new look at the collagen diseases. Some, like the Ehlers-Danlos syndrome, are now known to be the expression of primary molecular defects; others, such as scurvy and scleroderma, appear to be secondary to some process that disrupts normal controls over collagen synthesis or deposition.

• Authors: D J Prockop, N A Guzman
• Journal: Hospital practice (Hosp Pract) Vol. 12 Issue 12 Pg. 61-8 (Dec 1977) ISSN: 0018-5809 [Print] United States
• PMID: 924426 (Publication Type: Journal Article)

Chemical References

• Procollagen
• RNA, Messenger
• Collagen

Topics

• Amino Acid Sequence
• Collagen (biosynthesis)
• Collagen Diseases (metabolism)
• Ehlers-Danlos Syndrome (metabolism)
• Endoplasmic Reticulum (metabolism)
• Extracellular Space (metabolism)
• Humans
• Hydroxylation
• Molecular Conformation
• Procollagen (metabolism)
• Protein Biosynthesis
• RNA, Messenger (physiology)
• Scleroderma, Systemic (metabolism)
• Structure-Activity Relationship