[The efficacy of antithrombotic therapy after total obliteration-reversing therapy in atherosclerotic arterial occlusion of the lower extremities].

Abstract

The operation of total desobliteration of the arteries (TDA) is a modification of semi-open eversive endarterectomy (EAE). Under study was frequency of thromboses of the desobliteration area, its correlation with postoperative changes of the state of hemorheology and hemocoagulation and the antithrombotic treatment of 150 patients who were operated upon for total desobliteration of the iliofemoral-popliteal segment. The patients were divided into 2 groups which had no substantial difference. At the postoperative period patients of the 1st group (79) were treated with Ticlid ("Sanofi" France) in dosage of 500 mg/day. Treatment of 71 patients of the second group included a combination of two medicines (A + D): aspirin--1000 mg/day and dipiridamol--150 mg/day. A comparative analysis of frequency of the development of cardio-vascular complications at the remote period has shown that in the first group of patients the frequency of development of acute myocardial infarction and acute disturbance of cerebral blood circulation was two times less than in the second group of patients. It is to be noted that in case of the developed in time occlusion in the operation area, the extremity was saved in the Ticlid group in 62% of cases (7 amputations per 18 cases of reocclusion) while in the (A + D) group the extremity was saved in 29% (17 amputations per 24 cases of thrombosis). Thus, the investigation of long-term results of TDA in combination with postoperative antithrombotic therapy of patients with atherosclerotic occlusions of the iliofemoral-popliteal segment arteries has shown high effectiveness of Ticlid. As compared with traditional methods of treatment with aspirin and dipiridamol treatment with Ticlid allowed the cases of restenosis and reocclusions to become more than two times less often.

• Authors: Iu V Luk'ianov, V M Sedov, L V Lebedev, V V Shlomin, I V Kas'ianov, I V Batalin, V M Kondrat'ev
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Vol. 156 Issue 1 Pg. 62-5 ( 1997) ISSN: 0042-4625 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' antitromboticheskoĭ terapii posle total'noĭ dezobliterapii pri ateroskleroticheskoĭ okkliuzii arteriĭ nizhnikh konechnosteĭ.
• PMID: 9163197 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Fibrinolytic Agents

Topics

• Arteriosclerosis (complications, therapy)
• Combined Modality Therapy
• Drug Therapy, Combination
• Endarterectomy (adverse effects, methods)
• Female
• Fibrinolytic Agents (therapeutic use)
• Follow-Up Studies
• Humans
• Leg (blood supply)
• Male
• Middle Aged
• Postoperative Care
• Postoperative Complications (epidemiology, prevention & control)
• Recurrence
• Risk Factors
• Thrombosis (epidemiology, prevention & control)