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HIV integrase: a target for AIDS therapeutics.

Abstract
HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.
AuthorsM Thomas, L Brady
JournalTrends in biotechnology (Trends Biotechnol) Vol. 15 Issue 5 Pg. 167-72 (May 1997) ISSN: 0167-7799 [Print] England
PMID9161051 (Publication Type: Journal Article, Review)
Chemical References
  • HIV Integrase Inhibitors
  • HIV Integrase
Topics
  • Acquired Immunodeficiency Syndrome (drug therapy, virology)
  • Biotechnology
  • HIV (enzymology)
  • HIV Integrase (chemistry, metabolism)
  • HIV Integrase Inhibitors (therapeutic use)
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Protein Conformation
  • Virus Integration

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