Abstract |
Himachalol (a sesquiterpene alcohol) showed low in vitro minimum inhibitory concentrations against Aspergillus fumigatus by the macro- and microbroth dilution techniques (genometric mean 250 micrograms ml-1 and 46.4 micrograms ml-1 respectively) compared with saperconazole. Swiss mice treated with the phytoproduct (200 mg kg-1, p.o.) once daily for 7 days exhibited a significant (P < 0.001) protection (60%) together with an increase in the mean survival time (15 days) and a reduced CFU (mean log10) burden of A. fumigatus in the kidneys.
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Authors | L Chowdhry, Z K Khan, D K Kulshrestha |
Journal | Mycoses
(Mycoses)
1996 Nov-Dec
Vol. 39
Issue 11-12
Pg. 449-52
ISSN: 0933-7407 [Print] Germany |
PMID | 9145002
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Azoles
- Benzocycloheptenes
- Polycyclic Sesquiterpenes
- Sesquiterpenes
- himachalol
- saperconazole
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Topics |
- Animals
- Antifungal Agents
(pharmacology, therapeutic use)
- Aspergillosis
(drug therapy)
- Aspergillus fumigatus
(drug effects, isolation & purification)
- Azoles
(pharmacology)
- Benzocycloheptenes
(pharmacology, therapeutic use)
- Humans
- Male
- Mice
- Microbial Sensitivity Tests
- Polycyclic Sesquiterpenes
- Sesquiterpenes
(pharmacology, therapeutic use)
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