Abstract |
The decrease in titer of PRV antibodies in serum was evaluated at 10, 37, 67, 109 and 173 days of age in 16 non-vaccinated pigs and 43 pigs vaccinated at 3, 67 and 80 days of age with a modified live TK/gIII gene deleted pseudorabies virus (PRV) vaccine. Serum samples were analyzed for antibodies to PRV by the serum-virus neutralization test (SN), a commercial competitive ELISA (CELISA), and the CELISA OMNIMARK PRV differential (OMD) diagnostic kit. At 10 days of age, all pigs had SN titers > or = 1:4 and were CELISA+/OMD+, indicating circulating antibodies to field strains of PRV. At 109 days, all non-vaccinated pigs had SN titers < 1:4. Forty-five percent of vaccinated pigs had SN titers > or = 1:4, 56% were CELISA positive and most were CELISA+/OMD-, indicating antibodies due to vaccination. At 24 weeks of age, all pigs had SN titers > or = 1:4 and were CELISA+/OMD+ due to exposure to field strains. Although circulating maternal antibodies interfere with the development of active immunity, vaccination at 3 days of age resulted in detectable antibodies by 67 days of age, and a limited immune response could be measured at 109 days of age.
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Authors | F Elvinger, D E Reeves, A R Pursell, J R Cole, H Liauw |
Journal | Veterinary microbiology
(Vet Microbiol)
Vol. 42
Issue 4
Pg. 341-8
(Dec 1994)
ISSN: 0378-1135 [Print] Netherlands |
PMID | 9133059
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Viral
- Pseudorabies Vaccines
- Vaccines, Attenuated
- Viral Vaccines
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Topics |
- Animals
- Animals, Newborn
- Antibodies, Viral
(blood)
- Female
- Herpesvirus 1, Suid
(immunology)
- Immunity, Maternally-Acquired
(immunology)
- Pseudorabies
(immunology, prevention & control)
- Pseudorabies Vaccines
- Swine
- Swine Diseases
(immunology, prevention & control)
- Time Factors
- Vaccines, Attenuated
(administration & dosage, immunology)
- Viral Vaccines
(administration & dosage, immunology)
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