Abstract | BACKGROUND AND OBJECTIVES: Trichomonas vaginalis is a common vaginal pathogen. Oral metronidazole is the drug of choice for the treatment of trichomoniasis. Oral metronidazole, however, may cause unpleasant side effects and is contraindicated during the first trimester of pregnancy. In vitro studies and preliminary clinical data have suggested that intravaginal clotrimazole may be effective against this pathogen. GOALS: STUDY DESIGN: RESULTS: The number of patients who had positive cultures after treatment were 40/45 (88.9%) in the clotrimazole group, 35/43 (81.4%) in the AVC suppository group, and 9/45 (20%) in the metronidazole group (P < 0.001). All treatments were associated with a reduction in reported symptoms. Oral metrohidazole was more effective in reducing symptoms than either of the topical preparations. Adverse events, mostly mild or moderate in severity, were reported by 7 (14.6%) of 48 patients who had received oral metronidazole and 4 (7.8%) of 51 women who used AVC suppositories. There were no adverse events reported by the 50 women who used clotrimazole vaginal tablets. CONCLUSIONS:
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Authors | L duBouchet, M R Spence, M F Rein, M R Danzig, W M McCormack |
Journal | Sexually transmitted diseases
(Sex Transm Dis)
Vol. 24
Issue 3
Pg. 156-60
(Mar 1997)
ISSN: 0148-5717 [Print] United States |
PMID | 9132982
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Antitrichomonal Agents
- Sulfanilamides
- Metronidazole
- Sulfanilamide
- Allantoin
- Aminacrine
- Clotrimazole
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Topics |
- Administration, Intravaginal
- Administration, Oral
- Adolescent
- Adult
- Allantoin
(administration & dosage)
- Aminacrine
(administration & dosage)
- Antitrichomonal Agents
(administration & dosage)
- Clotrimazole
(administration & dosage)
- Female
- Humans
- Metronidazole
(administration & dosage)
- Middle Aged
- Sulfanilamide
- Sulfanilamides
(administration & dosage)
- Trichomonas Vaginitis
(drug therapy)
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