Cell-adhesion proteins of the immunoglobulin superfamily in the nervous system.

Abstract

The unique groups of cell-adhesion proteins, such as IgSF, play essential parts in the formation and maintenance of the nervous system. Recent crystallographic studies have revealed a possible common structure of cell-adhesion proteins. The IgSF proteins are sub-grouped into simple, complex and mixed types. Accumulating evidence reveals the importance of cell-adhesion proteins in neural morphogenesis, maintenance and regeneration. They play key roles in neuronal migration, neurite outgrowth promotion, neurite fasciculation, pathfinding, target recognition, synaptogenesis and myelination. Mutations of cell-adhesion proteins result in neurological disease; for example, mutations of PO in hereditary neuropathy and mutations of L1 in hereditary hydrocephalus, MASA syndrome and spastic paraplegia type 1. Perspectives of the studies of neural cell-adhesion proteins are discussed.

• Authors: K Uyemura, H Asou, T Yazaki, Y Takeda
• Journal: Essays in biochemistry (Essays Biochem) Vol. 31 Pg. 37-48 ( 1996) ISSN: 0071-1365 [Print] England
• PMID: 9078456 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cadherins
• Cell Adhesion Molecules, Neuronal
• Immunoglobulin M
• Immunoglobulins
• Neural Cell Adhesion Molecules
• Receptors, Antigen, T-Cell

Topics

• Animals
• Cadherins (chemistry)
• Cell Adhesion Molecules, Neuronal (chemistry, classification, physiology)
• Humans
• Immunoglobulin M (chemistry, metabolism)
• Immunoglobulins (chemistry, classification, physiology)
• Models, Molecular
• Nervous System (chemistry)
• Nervous System Diseases (metabolism)
• Nervous System Physiological Phenomena
• Neural Cell Adhesion Molecules (chemistry, physiology)
• Receptors, Antigen, T-Cell (chemistry, physiology)