TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats.

Abstract

We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.

• Authors: A Kagaya, A J Tanra, H Shinno, A Kugaya, M Muraoka, T Oyamada, Y Uchitomi, S Yamawaki
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 103 Issue 1-2 Pg. 69-75 ( 1996) ISSN: 0300-9564 [Print] Austria
• PMID: 9026378 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• Plant Extracts
• Serotonin Receptor Agonists
• TJS 010
• 8-Hydroxy-2-(di-n-propylamino)tetralin

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
• Animals
• Anti-Anxiety Agents (pharmacology)
• Body Temperature (drug effects)
• Dose-Response Relationship, Drug
• Drug Synergism
• Male
• Plant Extracts (pharmacology)
• Posture (physiology)
• Rats
• Rats, Wistar
• Serotonin Receptor Agonists (pharmacology)