Blockade of K(ATP) channels with glibenclamide does not abolish preconditioning during demand ischemia.

Abstract

The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treated with placebo or glibenclamide before sequential exercise testing or atrial pacing. Glibenclamide did not affect the improvement in signs of ischemia in both protocols, indicating that opening of these channels is not a mechanism of this adaptive response in humans.

• Authors: S D Correa, S Schaefer
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 79 Issue 1 Pg. 75-8 (Jan 01 1997) ISSN: 0002-9149 [Print] United States
• PMID: 9024742 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Hypoglycemic Agents
• Potassium Channels
• Adenosine Triphosphate
• Glyburide

Topics

• Adaptation, Physiological
• Adenosine Triphosphate (pharmacology)
• Aged
• Cardiac Pacing, Artificial
• Double-Blind Method
• Electrocardiography
• Exercise Test
• Female
• Glyburide (pharmacology)
• Humans
• Hypoglycemic Agents (pharmacology)
• Male
• Middle Aged
• Myocardial Ischemia (physiopathology)
• Potassium Channels (drug effects, physiology)