Abstract |
Acid secretion in Pavlov pouches in dogs is known to increase after antrectomy in response to histamine and gastrin. Dogs with gastric fistulae were tested with histamine and tetragastrin as a control study. The vagal nerve fibers to the antrum were divided and the dogs underwent repeat testing. Finally an antrectomy was performed and final dose-response data were collected. After antrectomy there was an increased acid response to histamine and tetragastrin. We postulate that the vagal fibers innervating the antrum are probably not a factor in this increase. Furthermore, we believe that the increased acid secretion after antrectomy observed in the dog and the decrease known to occur in the human being is a species difference and is not related to the pouch method of study used in earlier studies of the antrectomized dog.
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Authors | H H Trout 3rd, J Elashoff, J W Harmon |
Journal | Gastroenterology
(Gastroenterology)
Vol. 73
Issue 3
Pg. 492-4
(Sep 1977)
ISSN: 0016-5085 [Print] United States |
PMID | 892347
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Animals
- Denervation
- Dogs
- Dose-Response Relationship, Drug
- Duodenum
(innervation)
- Gastric Fistula
(metabolism)
- Gastric Juice
(metabolism)
- Gastrins
(analogs & derivatives, pharmacology)
- Histamine
(pharmacology)
- Humans
- Pyloric Antrum
(innervation, surgery)
- Species Specificity
- Stimulation, Chemical
- Vagotomy
- Vagus Nerve
(physiology)
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