Abstract |
Six patients with severe paraphilia were treated with a long-acting gonadotrophin hormone releasing hormone analogue ( GnRH-a). In five cases, the antiandrogen treatment ended their deviant sexual behaviour and markedly decreased their sexual fantasies and activities without significant side-effects. The beneficial effects of this treatment were maintained for 7 years in the patient where there was the longest follow-up. Two patients abruptly withdrew front their antiandrogen treatment at the end of the first and third year, respectively. Both relapsed within 8-10 weeks. One of them asked for resumption of antiandrogen treatment. In another case, in order to phase out antiandrogen treatment, testosterone (T) was added to the GnRH-a. In spite of normal T levels, and of resumption of normal sexual activities and deviant fantasies, deviant sexual behaviour did not return. A smoother phasing out of GnRH-a treatment is thought to be better than an abrupt withdrawal. However, the duration of antiandrogen treatment necessary to ensure a complete disappearance of deviant sexual behaviour remains uncertain, but is at least 4 years.
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Authors | F Thibaut, B Cordier, J M Kuhn |
Journal | Psychoneuroendocrinology
(Psychoneuroendocrinology)
Vol. 21
Issue 4
Pg. 411-9
(May 1996)
ISSN: 0306-4530 [Print] England |
PMID | 8844879
(Publication Type: Case Reports, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Delayed-Action Preparations
- Gonadotropin-Releasing Hormone
- Testosterone
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Topics |
- Adolescent
- Adult
- Bipolar Disorder
(complications, drug therapy, psychology)
- Borderline Personality Disorder
(drug therapy, psychology)
- Delayed-Action Preparations
- Exhibitionism
(drug therapy, psychology)
- Gonadotropin-Releasing Hormone
(administration & dosage, adverse effects, agonists)
- Humans
- Intellectual Disability
(complications, psychology)
- Male
- Masturbation
- Paraphilic Disorders
(drug therapy, psychology)
- Pedophilia
(psychology)
- Personality Disorders
(drug therapy, psychology)
- Psychiatric Status Rating Scales
- Recurrence
- Substance Withdrawal Syndrome
(psychology)
- Testosterone
(blood)
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