Placental tyrosine transport and maternal phenylketonuria.

Abstract

Brush border and basal plasma membrane vesicles prepared from normal human placental syncytiotrophoblast have been used to study L-tyrosine transport across placenta in an attempt to investigate the aetiology of the fetal damage found in maternal phenylketonuria. The results suggest that competition for transport with a grossly raised L-phenylalanine concentration at the basal surface of the trophoblast is responsible for the suppressed delivery of L-tyrosine to the fetus across the placenta.

• Authors: Y Kudo, C A Boyd
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 85 Issue 1 Pg. 109-10 (Jan 1996) ISSN: 0803-5253 [Print] Norway
• PMID: 8834991 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tyrosine
• Phenylalanine

Topics

• Cell Membrane (physiology)
• Culture Techniques
• Female
• Humans
• Infant, Newborn
• Maternal-Fetal Exchange (physiology)
• Microvilli (physiology)
• Phenylalanine (blood)
• Placenta (metabolism)
• Pregnancy
• Trophoblasts (physiology)
• Tyrosine (blood)