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Encephalopathy induced by oral hypoglycemic drugs.

Abstract
Three patients experienced severe hypoglycemic encephalopathy during oral therapy of adult-onset diabetes mellitus. Disabling residual neurological deficits were observed in two of these patients. The insidious time course of drug-induced hypoglycemia appeared to prevent patient recognition of sustained hypoglycemia. These cases indicate the need for further caution in the administration of oral hypoglycemic agents.
AuthorsR W Turkington
JournalArchives of internal medicine (Arch Intern Med) Vol. 137 Issue 8 Pg. 1082-3 (Aug 1977) ISSN: 0003-9926 [Print] United States
PMID879949 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Hypoglycemic Agents
  • Phenformin
  • Chlorpropamide
Topics
  • Brain Diseases, Metabolic (chemically induced, diagnosis)
  • Chlorpropamide (adverse effects)
  • Diabetes Mellitus (therapy)
  • Female
  • Humans
  • Hypoglycemia (chemically induced)
  • Hypoglycemic Agents (adverse effects)
  • Male
  • Middle Aged
  • Neurologic Examination
  • Phenformin (adverse effects)

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