HLA class-I and class-II antigen association in rheumatoid arthritis at Varanasi, India.

Abstract

Clinical presentation of rheumatoid arthritis (RA) and its severity differs in different races. Genetic factors play a significant role in its predeliction. The present study was undertaken to find out association of HLA class I and class II antigens with rheumatoid arthritis prevalent in Asian Indians residing at Varanasi. Ninety rheumatoid arthritis patients strictly fulfilling American Rheumatism Association criteria were screened for prevalent HLA class I and class II antigen by Terasaki Microlympho-cytotoxicity test. Results were compared with 100 healthy controls and 35 Seronegative Spondyloarthritides cases (SSA). Rheumatoid arthritis patients showed increased frequency of HLA-A2 and B40 antigens compared to healthy controls (p < .001). SSA patients showed significantly increased Phenotype frequency (PF) of HLA-B27 (p < .0001) and B40 (p < .001). Significant detection of HLA-A2 exclusively in RA patients suggests a more positive association of A2 in rheumatoid arthritis at Varanasi. HLA-B40 could not be attributed absolute significance of association with SSA or RA as it showed increased frequency in both diseases.

• Authors: V Agrawal, R M Gupta, Usha, S V Sharma
• Journal: Indian journal of pathology & microbiology (Indian J Pathol Microbiol) Vol. 39 Issue 1 Pg. 19-25 (Jan 1996) ISSN: 0377-4929 [Print] India
• PMID: 8755127 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histocompatibility Antigens Class I
• Histocompatibility Antigens Class II

Topics

• Adult
• Arthritis, Rheumatoid (ethnology, immunology)
• Histocompatibility Antigens Class I (analysis)
• Histocompatibility Antigens Class II (analysis)
• Humans
• India