Topical analgesia for superficial corneal injuries.

Abstract

OBJECTIVE:

To assess the analgesic effects of a topical non-steroidal anti-inflammatory agent, flurbiprofen 0.03%, during healing after superficial corneal injuries.

METHODS:

401 patients treated for corneal abrasion in a five month period were randomly allocated to one of four treatment groups: polyvinyl alcohol alone (control), homatropine 2%, flurbiprofen 0.03%, or homatropine 2% followed by flurbiprofen 0.03%. Treatments were given for 48 h. Ocular pain was recorded on a visual analogue scale by the patients over the first 24 h, and use of oral analgesics was also recorded. Usable responses were received from 224 patients (55.8%).

RESULTS:

Patients treated with flurbiprofen had significantly lower pain scores for the 24 h duration of the study than controls (P < 0.05).

CONCLUSIONS:

Flurbiprofen eye drops provide more effective pain relief than traditional treatments for superficial corneal injuries.

• Authors: A K Brahma, S Shah, V F Hillier, D McLeod, T Sabala, A Brown, J Marsden
• Journal: Journal of accident & emergency medicine (J Accid Emerg Med) Vol. 13 Issue 3 Pg. 186-8 (May 1996) ISSN: 1351-0622 [Print] England
• PMID: 8733656 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Parasympatholytics
• Tropanes
• Flurbiprofen
• homatropine
• Polyvinyl Alcohol

Topics

• Administration, Topical
• Adult
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Corneal Injuries
• Drug Administration Schedule
• Drug Therapy, Combination
• Eye Injuries (drug therapy, etiology, physiopathology)
• Female
• Flurbiprofen (administration & dosage, therapeutic use)
• Humans
• Male
• Pain (drug therapy, etiology)
• Pain Measurement
• Parasympatholytics (administration & dosage, therapeutic use)
• Polyvinyl Alcohol (administration & dosage, therapeutic use)
• Treatment Outcome
• Tropanes (administration & dosage, therapeutic use)