Cisapride as a successful treatment for acute intestinal pseudo-obstruction.

Abstract

Cisapride has been used in the treatment of chronic intestinal pseudo-obstruction with some success; however, the use of cisapride in the treatment of acute pseudo-obstruction has not been adequately studied. We describe a case of acute intestinal pseudo-obstruction successfully treated with cisapride. To our knowledge, this is the second such case reported in the English language literature. Our patient's acute intestinal pseudo-obstruction was probably precipitated by pneumonia and sepsis, and the prompt resolution of his intestinal pseudo-obstruction after initiation of cisapride therapy (despite progressive deterioration of his overall clinical status) implicates cisapride as the cause of the improved intestinal function. Therefore, we suggest that a trial of cisapride be considered for patients with acute intestinal pseudo-obstruction when other therapeutic maneuvers have failed.

• Authors: B W Mazloum, J B Barnes, M Lee
• Journal: Southern medical journal (South Med J) Vol. 89 Issue 8 Pg. 828-30 (Aug 1996) ISSN: 0038-4348 [Print] United States
• PMID: 8701389 (Publication Type: Case Reports, Journal Article)

Chemical References

• Parasympathomimetics
• Piperidines
• Cisapride

Topics

• Acute Disease
• Cisapride
• Colonic Diseases (diagnostic imaging, drug therapy, etiology)
• Fatal Outcome
• Humans
• Intestinal Pseudo-Obstruction (diagnostic imaging, drug therapy, etiology)
• Male
• Middle Aged
• Parasympathomimetics (therapeutic use)
• Piperidines (therapeutic use)
• Radiography