Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis.

Abstract

Thirty-nine patients with rheumatoid arthritis were HLA typed for the full range of A and B locus specificities and for Cw3 and Dw4. HLA-Dw4 was significantly more frequent in patients (36%) than in controls (13%). The frequency of Cw3 was also increased, probably because this allele is in linkage disequilibrium with Dw4.

• Authors: A J McMichael, T Sasazuki, H O McDevitt, R O Payne
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 20 Issue 5 Pg. 1037-42 (Jun 1977) ISSN: 0004-3591 [Print] United States
• PMID: 869952 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA Antigens
• Histocompatibility Antigens

Topics

• Alleles
• Arthritis, Rheumatoid (genetics, immunology)
• Female
• Gene Frequency
• Genetic Linkage
• HLA Antigens (analysis)
• Histocompatibility Antigens (analysis)
• Homozygote
• Humans
• Male