Cytogenetic remission induced by interferon-alpha in a myeloproliferative disorder with trisomy 8.

Abstract

We report a case of an unusual myeloproliferative disorder with trisomy of chromosome 8 characterized by peripheral blood thrombocythaemia and pronounced bone marrow myelodysplastic features. Treatment with interferon-alpha at intermediate dosages, together with a complete bone marrow and peripheral blood haematology remission, was able to induce a cytogenetic remission, shown by the complete disappearance at the conventional cytogenetic analysis of trisomy 8 abnormality characterizing the neoplastic clone at diagnosis. However, trisomy 8 was still detectable by FISH in a small proportion of cells, showing that profound suppression of, but not complete eradication of, the neoplastic clone had occurred. The ability of interferon-alpha to induce a major cytogenetic remission in a +8, Philadelphia-chromosome negative, myeloproliferative disorder has not previously been documented and may provide further indications for the use of this drug in these disorders.

• Authors: M Petrini, P Simi, G Saglio
• Journal: British journal of haematology (Br J Haematol) Vol. 92 Issue 4 Pg. 941-3 (Mar 1996) ISSN: 0007-1048 [Print] England
• PMID: 8616089 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interferon-alpha

Topics

• Adult
• Chromosomes, Human, Pair 8
• Humans
• In Situ Hybridization, Fluorescence
• Interferon-alpha (therapeutic use)
• Male
• Myeloproliferative Disorders (genetics, therapy)
• Trisomy