Abstract |
To evaluate the effects of roxithromycin in patients with chronic lower respiratory tract disease including diffuse panbronchiolitis, we studied lymphocyte function-associated antigen-1 (LFA-1) and Mac-1, neutrophil adhesion molecules, using peripheral neutrophils from healthy volunteers and from patients with chronic lower respiratory tract disease. The number of Mac-1 expressed on neutrophils of the patients was significantly greater (0.68 +/- 0.16) than in the healthy subjects (0.45 +/- 0.14), while the number of LFA-1 expressed on neutrophils of the patients was nearly similar to that in the healthy volunteers (0.95 +/- 0.10 vs 0.89 +/- 0.11). The neutrophil numbers in bronchoalveolar lavage fluid and the number of Mac-1 expressed on peripheral neutrophils significantly decreased in all patients who responded clinically to a low dose of roxithromycin for a long period of time (56.0 +/- 25.2 vs. 22.7 +/- 19.7%, p < 0.05 and 0.70 +/- 0.16 vs. 0.59 +/- 0.08, p < 0.05, respectively), whereas roxithromycin had no effect on the quantitative expression of LFA-1 (0.96 +/- 0.14 to 1.00 +/- 0.09, not significant) in all responders.
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Authors | S Kusano, J Kadota, S Kohno, K Iida, K Kawakami, T Morikawa, K Hara |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 62
Issue 4
Pg. 217-22
( 1995)
ISSN: 0025-7931 [Print] Switzerland |
PMID | 8578018
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Lymphocyte Function-Associated Antigen-1
- Macrophage-1 Antigen
- Roxithromycin
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Bronchoalveolar Lavage Fluid
(chemistry, cytology)
- Chronic Disease
- Humans
- Lymphocyte Function-Associated Antigen-1
(metabolism)
- Macrophage-1 Antigen
(metabolism)
- Middle Aged
- Neutrophils
(drug effects, metabolism)
- Reference Values
- Respiratory Tract Diseases
(drug therapy, metabolism)
- Roxithromycin
(therapeutic use)
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