Effects of a thromboxane synthase inhibitor (CS-518) on the eosinophil-dependent late asthmatic response and airway hyperresponsiveness in guinea pigs.

Abstract

The effects of CS-518, a thromboxane A2 synthase inhibitor, on antigen-induced dual bronchial responses, airway hyperresponsiveness (AHR) and airway eosinophilia were investigated in an experimental guinea pig model of the late asthmatic response. Oral CS-518 (1 and 10 mg/kg) inhibited immediate and late asthmatic responses dose-dependently. It also inhibited AHR and eosinophil accumulation after antigen challenge. Therefore, thromboxane A2 is possibly involved in development of the late asthmatic response and AHR, and CS-518 was inferred to inhibit these via inhibition of eosinophil accumulation and thromboxane production.

• Authors: K Itoh, E Takahashi, O Mukaiyama, Y Satoh, T Yamaguchi
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 109 Issue 1 Pg. 79-85 (Jan 1996) ISSN: 1018-2438 [Print] Switzerland
• PMID: 8527955 (Publication Type: Journal Article)

Chemical References

• Enzyme Inhibitors
• Thiophenes
• Methacholine Chloride
• RS 5186
• Ovalbumin
• Thromboxane-A Synthase

Topics

• Animals
• Asthma (etiology, prevention & control)
• Bronchial Hyperreactivity (etiology, prevention & control)
• Bronchial Provocation Tests
• Bronchoalveolar Lavage Fluid (cytology)
• Chemotaxis, Leukocyte
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Enzyme Inhibitors (pharmacology, therapeutic use)
• Eosinophils (immunology)
• Guinea Pigs
• Male
• Methacholine Chloride
• Ovalbumin (immunology)
• Pulmonary Eosinophilia (etiology, prevention & control)
• Thiophenes (pharmacology, therapeutic use)
• Thromboxane-A Synthase (antagonists & inhibitors)