Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats.

Abstract

Inflammation was induced in the lateral prostate of castrated Wistar rats by exposure to a sc implant of estradiol-filled Silastic tubing, followed by the addition of a dihydrotestosterone implant to restore prostatic wet weight. The presence of inflammation was correlated with increased serum PRL, elevated pituitary weight, and a greater than 2-fold increase in the lateral prostate DNA concentration. The administration of bromocriptine (4 mg/kg.day) to these animals was effective in suppressing pituitary weight and hyperprolactinemia and mitigated the lateral prostate inflammatory response. Inflammation was restored in the bromocriptine-treated hormone-implanted rats by administering exogenous ovine PRL at a dose of 2 mg/kg twice a day. The results indicate that estradiol-induced inflammation in the rat lateral prostate is mediated at least in part by the release of PRL from the pituitary.

• Authors: L Tangbanluekal, C L Robinette
• Journal: Endocrinology (Endocrinology) Vol. 132 Issue 6 Pg. 2407-16 (Jun 1993) ISSN: 0013-7227 [Print] United States
• PMID: 8504745 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Dihydrotestosterone
• Estradiol
• Prolactin
• DNA

Topics

• Animals
• DNA (metabolism)
• Dihydrotestosterone (metabolism)
• Estradiol
• Male
• Organ Size
• Osmolar Concentration
• Pituitary Gland (pathology)
• Prolactin (blood, physiology)
• Prostate (metabolism)
• Prostatitis (chemically induced, pathology)
• Rats
• Rats, Wistar