[Two cases of acute leukemia with t(6;9) (p23;q34)].

Abstract

Two cases of acute leukemia with a t (6;9) (p23;34) chromosome abnormality are reported. The first case was a 34-year-old female who was hospitalized in October 1989. A diagnosis of FAB-M1 was made. Chromosomal analysis of the bone marrow cells showed a 46, XX, t (6;9) (p23;q34). Complete remission was achieved after two courses of BHAC-DMP therapy. In September 1991, at the time of relapse, chromosomal analysis revealed two abnormal clones consisting of a 46, XX, t (6;9) (p23;q34), -12, -17, +der (12) t (12;17) (p11.2;q11.2) with a residual normal clone. She died in February 1992. The second case was a 42-year-old male who was hospitalized in January 1990. He was diagnosed as having RAEB. Chromosomal analysis of the bone marrow cells showed 46, XY, t (6;9) (p23;q34). Three months later, the disease progressed to acute leukemia accompanied by leg ulceration with leukemic cell infiltration. Small-dose ara-C therapy was given, but with no effect. After two subsequent courses of therapy with low-dose etoposide, complete remission was achieved. Four months later, relapse occurred, and the patient died of sepsis in February 1991. In the literature, 31 cases of myeloproliferative disorders with t (6;9) have been reported.

• Authors: T Ito, K Suyama, R Tsukahara, H Matsuoka, N Yokose, K Miyake, E An, M Futaki, K Inokuchi, K Ogata
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 34 Issue 1 Pg. 50-6 (Jan 1993) ISSN: 0485-1439 [Print] Japan
• PMID: 8450608 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Topics

• Acute Disease
• Adult
• Female
• Humans
• Leukemia (genetics)
• Male
• Translocation, Genetic