A comparative study of the immune responses of sheep against foot-and-mouth disease virus types Asia-1 and O PEG-concentrated aluminium hydroxide gel and oil-adjuvanted vaccines.

Abstract

Foot-and-mouth disease (FMD) vaccines prepared against types Asia-1 and O PEG-concentrated and adjuvanted with aluminium hydroxide gel were compared with oil-adjuvanted types Asia-1 and O vaccines in sheep. The study was conducted by inoculating 0.5 ml of monovalent vaccine under laboratory conditions and 1 ml dose of bivalent vaccine in field conditions. The antibody responses were monitored by serum neutralization and ELISA tests. The results indicate that PEG-concentrated gel vaccine was of comparable immunogenicity to oil-adjuvanted vaccine over a study period of 8 weeks. No significant difference was observed in the antibody response with monovalent or bivalent vaccine. However, to substantiate the present findings and reach a final conclusion, further studies with both vaccines may have to be carried out over a longer period of time.

• Authors: S P Nair, A K Sen
• Journal: Vaccine (Vaccine) Vol. 11 Issue 7 Pg. 782-6 ( 1993) ISSN: 0264-410X [Print] Netherlands
• PMID: 8393608 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antibodies, Viral
• Viral Vaccines
• Polyethylene Glycols
• Aluminum Hydroxide

Topics

• Adjuvants, Immunologic
• Aluminum Hydroxide
• Animals
• Antibodies, Viral (biosynthesis)
• Aphthovirus (immunology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Guinea Pigs
• Male
• Neutralization Tests
• Polyethylene Glycols
• Sheep (immunology)
• Vaccination
• Viral Vaccines (immunology)