Hemostatic study before onset of disseminated intravascular coagulation.

Abstract

Early diagnosis is necessary for the treatment of disseminated intravascular coagulation (DIC), but criteria for the stage preceding the diagnosis of DIC (pre-DIC) have not yet been established. To clarify hemostatic abnormalities that occur before the onset of DIC, we performed hemostatic studies in 117 patients within at least a week before the onset of DIC (pre-DIC), in 237 patients with DIC, and in 50 patients without DIC or pre-DIC (non-DIC). Levels of FDP, PT, and fibrinogen, and platelet counts were significantly abnormal after the onset of DIC, but not before. Thrombin-antithrombin III complex (TAT), plasmin-alpha 2 plasmin inhibitor complex (PIC), and FDP-D-dimer levels were significantly higher before the onset of DIC compared to the non-DIC patients. Hemostatic abnormalities were observed within a week before the onset of DIC. Monitoring the plasma levels of TAT, PIC, and FDP-D-dimer might be useful for the diagnosis of a pre-DIC condition.

• Authors: H Wada, K Minamikawa, Y Wakita, T Nakase, T Kaneko, M Ohiwa, S Tamaki, A Deguchi, Y Mori, K Deguchi
• Journal: American journal of hematology (Am J Hematol) Vol. 43 Issue 3 Pg. 190-4 (Jul 1993) ISSN: 0361-8609 [Print] United States
• PMID: 8352234 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrin Fibrinogen Degradation Products
• antithrombin III-protease complex
• Antithrombin III
• Peptide Hydrolases

Topics

• Antithrombin III (analysis)
• Blood Coagulation
• Disseminated Intravascular Coagulation (blood, diagnosis)
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinolysis
• Hemostasis
• Humans
• Peptide Hydrolases (analysis)
• Time Factors