Abstract |
Major histocompatibility complex antigens (HLA-ABC and -DR loci) on lymphocytes from 79 patients with La Crosse encephalitis were compared with those of 69 control subjects. Nine patients (11%) and none of the control population had HLA-B49 (P < .01, uncorrected for multiple comparisons). Of La Crosse encephalitis patients with acute-phase seizures, only 2 (7%) were positive for HLA-DR5, whereas 16 (37%) of nonseizure patients were positive for that antigen (P < .025). These findings suggest that susceptibility and complications associated with this disease may have an immunogenetic component.
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Authors | K L Case, R M West, M J Smith |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 168
Issue 2
Pg. 358-60
(Aug 1993)
ISSN: 0022-1899 [Print] United States |
PMID | 8335971
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA Antigens
- HLA-DR Antigens
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Topics |
- Encephalitis Virus, California
- Encephalitis, California
(immunology)
- HLA Antigens
(immunology)
- HLA-DR Antigens
(immunology)
- Humans
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