Study of potassium citrate treatment of crystalluric nephrolithiasis.

Abstract

Patients with crystalluric nephrolithiasis were treated orally with aqueous potassium citrate solution three times a day with a large quantity of water. After administration of potassium citrate, citric acid (P < 0.001) and potassium (P < 0.001) excretion was significantly increased. Increase in protein (P < 0.05) and uric acid (P < 0.05) excretion in urine revealed their association with the crystallization process. Crystals were absent in 12 (71%) out of 17 patients. Calcium excretion in urine was significantly decreased (P < 0.05). A decrease of calcium ions availability to oxalate ions to form calcium oxalate crystals may result in the prevention of calcium oxalate stone formation.

• Authors: M K Khanniazi, A Khanam, S A Naqvi, M A Sheikh
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 47 Issue 1 Pg. 25-8 ( 1993) ISSN: 0753-3322 [Print] France
• PMID: 8329662 (Publication Type: Journal Article)

Chemical References

• Antacids
• Citrates
• Uric Acid
• Citric Acid
• Calcium

Topics

• Adult
• Antacids (pharmacology, therapeutic use)
• Calcium (urine)
• Citrates (pharmacokinetics, therapeutic use)
• Citric Acid
• Crystallization
• Female
• Humans
• Kidney Calculi (chemistry, drug therapy)
• Male
• Proteinuria (chemically induced)
• Uric Acid (urine)